basic FUNCTION
| involved in proton-dependent uptake of di- or tri-peptides, and to a minor extent tetra-peptides |
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may participate in the intestinal absorption of peptide-based agents |
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could participate to recycling of peptides derived from extracellular and lysosomal thyroglobulin proteolysis, both essential steps for thyroid hormone synthesis |
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with AP3B1, and Hermansky-Pudlak syndrome proteins, are required for Toll-like receptor signaling in plasmacytoid dendritic cells |
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obscure solute channel protein, essential for TLR-mediated signaling in plasmacytoid dendritic cells |
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may also have a role in maintaining the appropriate pH of the endosomal compartment as endosomal acidification is required for optimal TLR7 and TLR9 activation |
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required for Plasmacytoid dendritic cells (pDCs) sensing of TLR ligands, is required to control persistent viral infection |
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lysosome-resident, proton-coupled amino-acid transporter that moves histidine and oligopeptides from inside the lysosome to the cytosol of eukaryotic cells |
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SLC15A4 transporter activity was necessary for the TLR-triggered cytokine production |