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FLASH GENE
Symbol RASSF6 contributors: mct/npt - updated : 06-06-2014
HGNC name Ras association (RalGDS/AF-6) domain family member 6
HGNC id 20796
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 4268 - 337 - 2007 17367779
isoform a
11 - 4323 - 369 - 2007 17367779
isoform b
10 - 5818 - 325 - 2007 17367779
10 - 5938 - 303 - 2007 17367779
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
Reproductivemale systemprostate   
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • Sav/RASSF/Hippo (SARAH) domain (Ikeda 2007)
  • a C-terminal Ras-association (RA) domain that binds activated Ras (Allen 2007)
  • HOMOLOGY
    Homologene
    FAMILY RASSF family proteins
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may play a role in dictating the degree of inflammatory response to the respiratory syncytial virus (Allen 2007)
  • demonstrates the properties of a Ras effector and tumor suppressor but exhibits biological properties that are unique and distinct from those of other family members (Allen 2007)
  • implicated in apoptosis in HeLa cells and it triggers both caspase-dependent and caspase-independent pathways (Ikeda 2007)
  • may function as tumour suppressors by regulating the cell cycle and apoptosis (van der Weyden 2007)
  • caused apoptosis when released from activated STK3 in a manner dependent on WW45, the mammalian Salvador homolog (Ikeda 2009)
  • antagonizes Hippo signaling and mediates apoptosis through a pathway that is parallel to the canonical Hippo pathway (Ikeda 2009)
  • stabilizes TP53, regulates apoptosis and the cell cycle, and functions as a tumor suppressor
  • involved in TP53-mediated G1/S arrest
  • RASSF6 may play a tumor suppressor role in the progression of clear cell renal cell carcinoma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds RAS
  • bound to STK3 (RASSF6 inhibited STK3 activity to antagonize Hippo signaling) (Ikeda 2009)
  • binds MDM2 and facilitates its ubiquitination
  • RASSF6 triggers CDKN1A accumulation to induce G 1 cell cycle arrest and promote apoptosis upon exposure to pro-apoptotic agents
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS