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FLASH GENE
Symbol GEN1 contributors: SGE/npt/shn - updated : 02-01-2011
HGNC name Gen homolog 1, endonuclease (Drosophila)
HGNC id 26881
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 6226 - 908 - -
14 - 6367 - 908 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Lymphoid/Immunethymus    
Nervousbrain    
Reproductivemale systemtestis   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to Gen1, Mus musculus
ortholog to Gen1, Rattus norvegicus
ortholog to GEN1, Pan troglodyte
ortholog to Yen1, yeast S.cerevisiae
Homologene
FAMILY
  • Rad2/XPG nuclease
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • promoting Holliday junction resolution wich is essential for chromosome segregation at meiosis and the repair of stalled/collapsed replication forks in mitotic cells
  • capable of cleaving replication fork and 5' flap substrates (Svendsen 2010)
  • FEN1, EXO1, ERCC5, and GEN1 are junction specific enzymes that require three separate binding sites for DNA and that incise one base pair into the duplex region of the substrate
  • GEN1 and the BTBD12-associated nucleases MUS81 and SLX1A are essential for the resolution of replication-induced Holliday junctions '
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • a monomeric 5'-flap endonuclease
  • a component
  • EXO1, ERCC5, and GEN1, whose activities span multiple DNA repair pathways, are members of the 5 prime nuclease superfamily with FEN1
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binding two Mg2+ ions per subunit
  • protein
    cell & other
  • Holliday junction resolution
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS