basic FUNCTION
| promoting Holliday junction resolution wich is essential for chromosome segregation at meiosis and the repair of stalled/collapsed replication forks in mitotic cells |
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capable of cleaving replication fork and 5' flap substrates (Svendsen 2010) |
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FEN1, EXO1, ERCC5, and GEN1 are junction specific enzymes that require three separate binding sites for DNA and that incise one base pair into the duplex region of the substrate |
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GEN1 and the BTBD12-associated nucleases MUS81 and SLX1A are essential for the resolution of replication-induced Holliday junctions ' |