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FLASH GENE
Symbol UNC13B contributors: mct/npt/pgu - updated : 02-02-2017
HGNC name unc-13 homolog B (C. elegans)
HGNC id 12566
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
39 - 6398 180.55 1591 - 1998 9736751
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...)
Urinaryepithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal 100AA stretch
  • three C2 domains
  • a diacylglycerol-binding C1 domain, that interacts with phorbol ester or diacylglycerol (DAG) and phospholipid
  • HOMOLOGY
    interspecies homolog to C.elegans Unc13-like
    homolog to murine Unc13h1
    Homologene
    FAMILY
  • Munc13 family
  • CATEGORY regulatory , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text with DOC2A highly concentrated on synaptic vesicles and the presynaptic plasma membrane
    basic FUNCTION
  • promoting the priming of synaptic vesicles by acting through syntaxin
  • mediated vesicle priming not restricted to neurotransmitter release but is also functional in insulin secretion
  • playing a potential role in mediating some of the acute and chronic changes in MC produced by exposure to hyperglycemia
  • with DOC2B are implicated in Ca2+-dependent neurotransmitter release
  • RAB3IL1 and its binding partner UNC13B, and the subsequent gating of vesicle fusion by activation of the Ca2+ channels, are implicated in the docking of vesicles at the transmitter release site, a process of neurosecretion
  • having essential function in synaptic vesicle priming and in the modulation of synaptic strength, and key regulator of these adaptive mechanisms
  • essential regulator of synaptic vesicle priming and playing a key role in adaptive synaptic plasticity phenomena
  • RAB34 and its effector UNC13B constitute a new pathway modulating protein secretion in the cellular response to hyperglycemia
  • UNC13B and UNC13C limit the ability of UNC13A to regulate calcium-dependent replenishment of readily releasable pool and slow pool to fast pool conversion in central synapses
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • syntaxin
  • FMR1 (RNA target of FMR1)
  • UNC13B serves as an effector of RAB34, mediating lysosome-Golgi trafficking
  • DOC2B-UNC13B interactions are stimulated by phorbol ester through the C1 domain of UNC13B
  • interaction between DOC2A and UNC13B is required for Ca2+-dependent neurotransmitter release from intact neuron
  • interaction with CALM1
  • UNC13B and RAB34 interact at the Golgi via the munc13 homology domain 2 (MHD2)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS