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FLASH GENE
Symbol NUDT8 contributors: mct - updated : 23-06-2022
HGNC name nudix (nucleoside diphosphate linked moiety X)-type motif 8
HGNC id 8055
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 745 - 236 - 2006 16712791
3 - 816 - 140 - 2006 16712791
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly Homo sapiens
Digestiveliver   highly Homo sapiens
Nervousbrain   highly Homo sapiens
Reproductivemale systemprostate   
Urinarykidney   highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadiposebrown highly Homo sapiens
Muscularstriatumskeletal moderately Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta, umbilical cord and umbilical cord blood
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Nudt/MutT (NUDIX) domain
  • N-terminus contains a putative mitochondrial targeting sequence within the first 24 AAs
  • HOMOLOGY
    Homologene
    FAMILY Nudix hydrolase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • hydrolase activity
  • is a novel CoA-degrading enzyme that resides in the mitochondria
  • characterization of NUDT8 as a mitochondrial CoA-degrading enzyme indicates that CoA degradation is not limited to the peroxisomes and may provide a common mechanism to regulate the subcellular pools of CoA in response to changes in the metabolic state
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mg2+
  • Mn2+
  • protein
  • NUDT8 specifically hydrolyzes CoA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS