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FLASH GENE
Symbol PRSS50 contributors: mct - updated : 17-01-2011
HGNC name protease, serine, 50
HGNC id 17910
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1363 - 385 - 1999 10397268
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningretinal pigment epithelium (RPE)  
Epithelialsensoryvisual  
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatocyte
cell lineage
cell lines mammary epithelial cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
Homologene
FAMILY
  • peptidase family S1
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • involved in the spermatogenesis
  • testis-specific gene that encoded a threonine protease
  • role in signal-dependent transcriptional regulation
  • can enhance the expression of NFKB target genes involved in cell proliferation, and promotes cell proliferation, at least partially, through activation of the NFKB signalling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with FGF2 (mediates PRSS50 downregulation by ERK activation, leading to the phosphorylation of Sp1 in this process)
  • CTCFL is directly responsible for the transcriptional activation of PRSS50
  • cell & other
    REGULATION
    activated by CTCFL
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    not only reduced cell proliferation, colony formation, and migration but also induced cell apoptosis in tumor cells
    tumoral     --over  
    in breast cancer cells and overexpression of PRSS50 can promote tumorigenesis
    tumoral     --low  
    in seminoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target development of new reagents for therapeutic downregulation of breast cancer
    ANIMAL & CELL MODELS