protein
| binding to mHtt (mutant Huntingtin) and induces sumoylation leading to the cytotoxicity (Subramaniam 2009) |
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binds to and activates PI3K (Vargiu 2004) |
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binds selectively to GNB1, GNB2 and GNB3 subunits (Hill 2009) |
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RASD1 with RASD2 modulate Ca(2+) influx through Ca(V)2.2 channels under more physiological conditions and thereby influence Ca(2+)-dependent events such as neurosecretion (Thapliyal 2008) |
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binds directly to both E1 and UBE2I, enhancing cross-sumoylation as well as thioester transfer from E1 to UBE2I |
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also binds and activates MTOR, enhancing its influence on protein synthesis, and may be the principal determinant of striatal MTOR activation |
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exerts some of its effects by interacting with G(alpha) i |
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striatal-specific protein, binding to and activates MTOR |
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interacts with PIK3R1, the regulatory subunit of PI3K |
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may be a co-factor with mutant huntingtin in cell death |
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robustly binds the autophagy regulator BECN1, decreasing its inhibitory interaction with BCL2 independent of MAPK8 signaling |