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FLASH GENE
Symbol CREB3L4 contributors: mct - updated : 23-12-2013
HGNC name cAMP responsive element binding protein 3-like 4
HGNC id 18854
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1747 - 395 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 pharynx   highly
 stomach   highly
Nervousnervespinal nervesciatic  
Reproductivemale systemprostate  highly
 male systemtestis   
Visualeyelacrimal gland   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text present throughout development
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal activation domain
  • a central bZIP domain
  • a predicted transmembrane domain
  • an adjacent cleavage site for the Golgi protease S1P, with conserved features which indicate that it represents a specific subclass of S1P sites
  • a C terminal transmembrane domain
  • HOMOLOGY
    interspecies ortholog to murine Creb3l4
    ortholog to rattus creb3l4
    Homologene
    FAMILY
  • BZIP family
  • CREB/ATF family transcription factor
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • transcriptional activator
  • binds to fat body-specific enhancers of alcohol dehydrogenase (ADH) and yolk protein genes BBF2
  • involved in regulation of transcription, DNA-dependent
  • may be playing an important role in prostate cancer and in androgen receptor signaling in prostate cells
  • probable targets for the amplification mechanism and may therefore be involved, together or separately, in the development or progression of Hepatocellular carcinoma (Inagaki 2008)
  • ER-resident transmembrane transcription factor that is structurally similar to CREB3L1
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CREB3L4 and CREB3L1 may form a heterodimer that promotes the expression of target genes required for the differentiation of goblet cells
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other cleaved in a site-specific manner in response to brefeldin A disruption of the Golgi or by coexpression with S1P but only after deletion or substitution of its C-terminal lumenal domain
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    by androgens in prostate tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS