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FLASH GENE
Symbol GPSM1 contributors: mlc/npt - updated : 04-01-2008
HGNC name G-protein signalling modulator 1 (AGS3-like, C. elegans)
HGNC id 17858
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1959 72.1 652 - Izaki (2006)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   moderately
Nervousbrain   highly
Reproductivefemale systemplacenta  moderately
 male systemtestis  moderately
Respiratorylung   moderately
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Muscular    
Nervouscentralwhite matter  
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text spleen, pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal seven tetratricopeptide repeats (the TPR domain), a mediator of protein-protein interaction
  • one WH1 domain
  • WH2 domain
  • C-terminal four G protein regulatory motifs [the GPR or GoLoco domain, a modulator of G protein signaling
  • HOMOLOGY
    interspecies ortholog to murine Gpsm1
    ortholog to rattus Ags3
    Homologene
    FAMILY
  • GPSM family
  • CATEGORY regulatory , signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • having GTPase activator activity, and involved in signal transduction
  • playing a critical role in drug addiction
  • involved in an early event during the autophagic pathway probably prior to the formation of the autophagosome
  • playing a potential role in the formation or maintenance of neural plasticity
  • modulating the protein trafficking along the transgolgi/network/plasma membrane/endosome loop
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS