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FLASH GENE
Symbol SPTSSB contributors: mct - updated : 22-12-2016
HGNC name serine palmitoyltransferase small subunit B
HGNC id 24045
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 3321 - 76 - 2005 15777716
3 - 2306 - 76 - 2005 15777716
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus    
Nervousbrain    
Reproductivefemale systembreastmammary gland  
 male systemprostate    Homo sapiens
Respiratoryrespiratory tracttrachea   
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to a putative G-protein coupled receptor
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
basic FUNCTION
  • shares sequence similarity to a putative G-protein coupled receptor indicating its possible role in signal transduction
  • SPTSSA, SPTSSB share a conserved hydrophobic central domain predicted to reside in the membrane, and each interacts with both SPTLC1 and SPTLC2
  • serine palmitoyltransferase (SPT) small subunits (SPTSSA, SPTSSB) play a major role in controlling SPT activity and substrate affinity, and in specifying sphingolipid long chain base (LCB) chain length
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with both SPTLC1 and SPTLC2
  • cell & other
    REGULATION
    inhibited by androgens
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS