motifs/domains
| N terminus functioning as a transcription factor to promote the expression of ER-Golgi trafficking-related genes and playing crucial roles in chondrocyte differentiation |
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a basic DNA-binding and leucine-zipper dimerization (B-ZIP) motif |
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a predicted transmembrane domain |
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an adjacent cleavage site for the Golgi protease S1P, with conserved features which indicate that it represents a specific subclass of S1P sites |
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a hydrophobic region predicted to be an alpha-helical transmembrane domain |
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secreted luminal CREB3L2 C-terminus that is involved in Hedgehog ligand-dependent cancer cell proliferation through activation of Hedgehog signaling , and is secreted into the extracellular space as a signaling molecule for cell-to-cell communication |
SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,nucleus,nucleoplasm
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text
| full-length CREB3L2 and FUS/CREB3L2 were localized to reticular structures of the cytoplasm |
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the corresponding, truncated proteins lacking the transmembrane domain and the carboxy-terminal part of CREB3L2 resided within the nucleus |
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localized in the ER and is cleaved in its transmembrane region in response to ER stress |
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ER-resident transmembrane transcription factor |
basic FUNCTION
| cyclin-dependent kinase inhibitor involved in regulation of transcription, DNA-dependent (transcriptional activation) |
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might contribute to only the late phase of unfolded protein response signaling (Kondo 2007) |
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ER stress transducer which could play important roles in preventing accumulation of unfolded proteins in damaged neurons (Kondo 2007) |
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activating transcription through B-Box and ATF6 elements |
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activating Sec23A transcription (Saito 2009) |
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CREB3L1 and CREB3L2, have the ability to up-regulate the secretory pathway in nonsecretory cell types |
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CREB3L2 and CREB3L1 are ER stress transducers with roles in chondrogenesis and osteogenesis |
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plays crucial roles as a bifunctional regulator to accelerate ECM protein secretion and suppress ER stress-induced apoptosis by activating the ATF5-MCL1 pathway during chondrogenesis |
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plays an essential role in the inhibition of apoptosis induced by ER stress during chondrocyte differentiation |
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is a novel regulator of the BDNF gene and may play an important role in the repair and/or regeneration of damaged neural tissues by specifically activating BDNF promoter II |
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is an endoplasmic reticulum (ER)-resident transmembrane basic leucine zipper (bZIP) transcription factor that is cleaved at the transmembrane domain by regulated intramembrane proteolysis in response to ER stress |
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UPR transducer CREB3L2 allows export of type II collagen in a cargo- and developmental stage-specific manner |