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FLASH GENE
Symbol TTLL12 contributors: mct - updated : 11-08-2021
HGNC name tubulin tyrosine ligase-like family, member 12
HGNC id 28974
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 3386 74 644 - 2017 28011935
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one TTL domain
  • HOMOLOGY
    interspecies homolog to C.elegans d2013.9
    Homologene
    FAMILY tubulin-tyrosine ligase (TTLL) family
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • localized in the cytosol
  • basic FUNCTION
  • has non-catalytic functions related to tubulin and histone modification, which could be linked to its effects on mitosis and chromosome number stability
  • has functions of histone methylation and affects the activities of tubulin tyrosine ligase
  • is a negative regulator of RNA-virus-induced type I IFN expression by inhibiting the interaction of VISA with other proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    associated with early and advanced stages, lymph nodes, distant metastases and risk factors such as H. pylori in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential molecular marker for predicting the invasion and progression of Ovarian cancer
  • Therapy target
    ANIMAL & CELL MODELS