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FLASH GENE
Symbol SH2D1B contributors: mct - updated : 18-07-2006
HGNC name SH2 domain containing 1B [Homo sapiens]
HGNC id 30416
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach    
Lymphoid/Immunespleen   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a functional SH2 domain
  • HOMOLOGY
    interspecies homolog to EWS/FLI1 activated transcript 2 murine,homolog
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • EWS/FLI1 activated transcript 2 murine homolog, involved in transformation of NIH3T3 cells and the oncogenesis of Ewing sarcoma
  • plays a role in controlling signal transduction through at least four receptors, CD84, CD150, CD229 and CD244, expressed on the surface of professional antigen-presenting cells
  • regulating signal transduction through receptors expressed on the surface of antigen-presenting cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to autism spectrum disorder
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS