Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GGCT contributors: mct/npt - updated : 17/09/2008
HGNC name gamma-glutamyl cyclotransferase
HGNC id 21705
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1186 21 188 - Oakley (2008)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately
 salivary gland   highly
Nervousbrain   highly
Reproductivefemale systembreastmammary gland moderately
Urinarybladder   highly
 kidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connectiveadipose  highly
Muscularstriatumskeletal moderately
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerythrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer dimer
HOMOLOGY
Homologene
FAMILY
  • BtrG-like family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • catalyzes the formation of 5-oxoproline (pyroglutamic acid) from gamma-glutamyl dipeptides and potentially plays a significant role in glutathione homeostasis
  • may play an important role in the induction of apoptosis by GGO in leukemia U937 cells
  • could play a significant role in regulating the synthesis of glutathione by limiting the availability of -glutamylcysteine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in kidney, mammary gland, and prostate tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target specific inhibitors that may be of value in the treatment of patients with glutathione synthetase deficiency or in manipulating cancer cell proliferation
    ANIMAL & CELL MODELS