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FLASH GENE
Symbol AP2S1 contributors: - updated : 18-07-2006
HGNC name adaptor-related protein complex 2, sigma 1 subunit
HGNC id 565
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 800 17 142 - Holzmann
- splicing 667 12 104 - Holzmann
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivestomach   highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
  • cultured leukemia cells
  • fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY clathrin adaptor complexes small chain proteins family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text cytoplasmic face of coated vesicles
    basic FUNCTION component of the adaptor complexes which link clathrin to receptors in coated vesicles
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • small chain component of the major clathrin adaptor complex AP2
  • heterotetramer composed of two large adaptins
  • (alpha1A/AP2A1 or alpha1B/AP2A1 or alpha2/AP2A2 and beta1/AP2B1), a medium adaptin (mu2/AP2M1) and
    a small adaptin (sigma2long/AP2S1 or sigma2short/AP2S1)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS