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FLASH GENE
Symbol POMP contributors: mct/npt - updated : 13-07-2018
HGNC name proteasome maturation protein
HGNC id 20330
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1377 16 141 - 2017 28728908
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
 salivary gland   highly
Endocrinethyroid   highly
Skin/Tegumentskin    
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningepidermis highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer dimer
HOMOLOGY
interspecies ortholog to murine Pomp (86 pc)
Homologene
FAMILY
  • POMP/UMP1 family
  • CATEGORY chaperone/stress , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text present in the cytoplasm as well as in the nucleus (Hoefer 2006)
    basic FUNCTION
  • acts as a chaperone and is essential for the maturation of the 20S proteasome proteolytic core complex (Hoefer 2006)
  • essential factor of mammalian proteasome biogenesis, recruiting beta-subunits stepwise and mediating the association of mammalian precursor complexes with the ER (Fricke 2007)
  • facilitates the main steps in 20S core complex formation at the ER to coordinate the assembly process and to provide cells with freshly formed proteasomes at their site of function (Fricke 2007)
  • role in proteasome assembly and further strengthen the prospect of genetic manipulation of the proteasomal system (Chondrogianni 2007)
  • functions as a chaperone for proteasome maturation (Dahlqvist 2010)
  • is required for 20S proteasome assembly and, thus, for efficient NFKB1 signaling
  • potential role for POMP and proteasome assembly in psoriasis pathogenesis
  • is a chaperone for proteasome assembly and is critical for the incorporation of catalytic subunits into the proteasome
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • is predicted to dimerize to participate in the formation of a half-mer and further tetramerize when two half-mers join to form a mature 20S proteasome consisting of two outer alpha rings and two inner beta rings
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) KLICK , PRAID
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS