basic FUNCTION
| acts as a chaperone and is essential for the maturation of the 20S proteasome proteolytic core complex (Hoefer 2006) |
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essential factor of mammalian proteasome biogenesis, recruiting beta-subunits stepwise and mediating the association of mammalian precursor complexes with the ER (Fricke 2007) |
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facilitates the main steps in 20S core complex formation at the ER to coordinate the assembly process and to provide cells with freshly formed proteasomes at their site of function (Fricke 2007) |
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role in proteasome assembly and further strengthen the prospect of genetic manipulation of the proteasomal system (Chondrogianni 2007) |
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functions as a chaperone for proteasome maturation (Dahlqvist 2010) |
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is required for 20S proteasome assembly and, thus, for efficient NFKB1 signaling |
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potential role for POMP and proteasome assembly in psoriasis pathogenesis |
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is a chaperone for proteasome assembly and is critical for the incorporation of catalytic subunits into the proteasome |