Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NTHL1 contributors: - updated : 22-03-2006
HGNC name nth endonuclease III-like 1 (E. coli)
HGNC id 8028
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestinecolon highly
 stomach   highly
Reproductivefemale systemovary  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure helix hairpin helix and glycine/proline-rich loop, a nuclear localization signal (NLS)
HOMOLOGY
interspecies homolog to E.coli nth endonuclease III-like 1
intraspecies homolog to HhH-GPD family of BER pathway
Homologene
FAMILY NTH/MUTY family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • having both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity
  • involved in the excision of damaged pyrimidines, purines (8 oxoguanine) end
  • bifunctional enzyme with DNA glycosylase and AP lyase activities
  • CELLULAR PROCESS nucleotide, repair, base excision repair
    PHYSIOLOGICAL PROCESS
    text base excision repair
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    nucleotide
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with TP53 and proliferating cell nuclear antigen
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS