basic FUNCTION
| activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation |
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acting both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt |
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proteins, and in a Wnt-independent beta catenin pathway through a receptor |
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play a major role in activating the Wnt/-catenin signaling pathway |
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having essential roles in vertebrate development and its ligand-type activities overlap substantially with those of the canonical Wnt ligands in that both Rspo and canonical Wnt signaling result in the activation of beta-catenin |
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potentiate Wnt/beta-catenin signaling, an important pathway in embryonic development that is constitutively active in many cancers |
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modulate the Wnt pathway by a common mechanism and coexpression with specific Wnt ligands and DKK1 may determine their biological specificity |
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RSPO1, RSPO2, RSPO3, RSPO4 can stimulate the proliferation of intestinal crypt stem cells, through enhancement of Wnt/CTNNB signaling |