protein
| inversin |
|
NPHP1 |
|
INVS is essential for the compartmental localization of NPHP3 and NEK8, whereas localization of INVS does not require NPHP3 or NEK8 |
|
ANKS6 is a new NPHP family member that connects NEK8 (NPHP9) to INVS (NPHP2) and NPHP3 |
|
UNC119 and PDED are acyl- and prenyl-binding proteins, respectively, involved in trafficking of acylated (transducin-alpha subunit, nephrocystin NPHP3) and prenylated protein |
|
GNAT1, NPHP3, and PKD1 bind with high affinity to UNC119, whereas a peptide derived from a non-ciliary localizing protein (SRC) has low affinity |
|
INVS and NPHP3 cooperate and promote ANKS6 phosphorylation by NEK8 in renal cilia |
|
primary cilia formation could be regulated by TMSB4X through its interaction with NPHP3 and/or the control of NPHP3 expression |