Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

HECW2

contributors: SGE/npt - updated : 05-01-2010

HGNC name	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
HGNC id	29853

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020760 29 - 6926 NP_065811 - 1572 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       predominantly Digestive liver         Nervous brain       predominantly Reproductive female system ovary         male system testis       Respiratory lung       predominantly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one C2 domain at its NH(2)-terminus
	two WW domains
	one HECT domain at its COOH-terminus

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to murine Hecw2 (95.2pc)
	homolog to rattus Hecw2 (94.7pc)

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	involved in protein modification, ubiquitin cycle
	E3 ubiquitin-protein ligase that mediates ubiquitination of TP73, to stabilize TP73 and enhance activation of transcription by TP73

CELLULAR PROCESS

protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with TP73

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS