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FLASH GENE
Symbol SOCS4 contributors: mct - updated : 17-03-2020
HGNC name suppressor of cytokine signaling 4
HGNC id 19392
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 6774 50.62 440 - 2015 26437444
a supplementary exon in the 5' region
3 splicing 6903 - 440 - 2015 26437444
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Hearing/Equilibriumearinnercochlea highly
Urinarybladder   highly
 kidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved region of about 70 AAs in the N-terminal domains of SOCS4 and 5 that is predicted to be more ordered than the surrounding sequence
  • one SOCS box domain
  • solitary central Src homology SH2 domain
  • a C terminal SOCS, CIS (CH domain) sequence
  • HOMOLOGY
    intraspecies homolog to SOCS5
    Homologene
    FAMILY SOCS family, STAT inducer STAT inhibitoiy protein faminy
    CATEGORY regulatory , signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in intracellular signaling cascade
  • regulate epidermal growth factor receptor signaling
  • is a critical regulator of anti-viral immunity
  • is a known inhibitor of epidermal growth factor (EGF) receptor signalling
  • is dispensable for an efficient recall response to influenza virus infection
  • SOCS3 and SOCS4 appear to play regulatory roles in a number of keratinocyte and endothelial cellular traits associated with the wound healing process
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SOCS4 reduces STAT3 signaling from EGFR through increased receptor degradation
  • CUL5 is a scaffold protein that recruits RNF7, the ELOB/ELOC complex, and SOCS box proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Alzheimer disease brains
    tumoral     --over  
    significantly associated with earlier tumour stage and better clinical outcome in human breast cancer
    constitutional germinal mutation      
    in autoimmune disorder
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking functional Socs4 are hypersusceptible to primary infection with influenza A virus (IAV), displaying dysregulated pro-inflammatory cytokine and chemokine production in the lungs