basic FUNCTION
| participating with LIS1 in the regulation of cytoplasmic dynein through phosphorylation by CDK5, complex essential for neuronal migration |
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cysteine peptidase, involved in the conversion and inactivation of a number of bioactive peptides |
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playing an essential role for mitotic cell division and neuronal migration not only via regulation of cytoplasmic dynein function but also by modulation of KATNA1 localization and function |
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facilitates cell migration by sequestering ARHGAP1 at the leading edge to stabilize active CDC42 in response to extracellular stimuli |
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acting with PAFAH1B1, and NDE1 in a common pathway to regulate dynein but each has distinct roles in the regulation of microtubule organization and neuronal migration |
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crucial role of NDEL1, together with DISC1 in cortical layer formation |
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releases the blocking effect of PAFAH1B1 on cytoplasmic dynein |
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essential for mitotic cell division and neuronal migration not only via regulation of cytoplasmic dynein function but also by modulation of KATNB1 localization and function |
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having a critical role for neuronal migration |
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cytoplasmic dynein regulator, that competes with CDC42 for binding ARHGAP1 |
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substrate of PPP4C, and PPP4C selectively dephosphorylates NDEL1 at CDK1 sites |
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regulates microtubule organization during spindle assembly independently of its function at kinetochores |
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regulates microtubule organization in part by facilitating assembly of the lamin B spindle matrix in a dynein-dependent manner |
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promotes assembly of the spindle matrix and MT organization |
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antagonistic effect of PAFAH1B2, PAFAH1B3 and NDEL1 for PAFAH1B1 binding, probably to modulate dynein functions |
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NDEL1-dependent microtubule self-organization requires an interaction between NDEL1 and dynein, which is mediated by the dimerization fragment of the coiled-coil |
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in axons, unphosphorylated NDEL1 inhibits the capacity of dynein to transport acidic organelles |
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is important for the early steps of the WAVE regulatory complex (WRC) assembly in vivo by antagonizing the instability of certain WRC subunits and subcomplexes |
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NDE1 (nuclear distribution element 1) and NDEL1 (NDE-like 1) are essential for mitosis and neurodevelopment |
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NDEL1, NUDCD3, PAFAH1B1 are critical components of cytoplasmic dynein complex |
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novel roles of PAFAH1B1, NDEL1 and NUDCD3 in the transport of mitochondria in axons |
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NDEL/NDE1 and PAFAH1B1 promote dynein and dynactin interaction in the context of spindle morphogenesis |
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NDE1, NDEL1 are essential for mitosis and neurodevelopment that have been implicated in psychiatric and neurodevelopmental disorders |
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NDEL1 enzyme activity is a complex trait influenced by many different genetic variants that may contribute to schizophrenia (SCZ) physiopathology |
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PLEKHM1, DEF8, FAM98A, and NDEL1 constitute a molecular complex that regulates lysosome positioning and secretion through RAB7 |
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CDK5, YWHAE, and CDK5 cofactor C2CD5 together promote NDEL1 phosphorylation and are essential for force adaptation |
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