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FLASH GENE
Symbol TMEM259 contributors: mct - updated : 19-03-2020
HGNC name transmembrane protein 259
HGNC id 17039
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2587 - 408 in breast or pancreatic carcinomas 2005 16084606
  • also called variant 2 or membralin-3
  • contains all exons except for exon 10
  • 11 - 2754 - 620 expressed in ovarian and colorectal carcinomas but not in breast or pancreatic carcinomas 2005 16084606
    also called variant 1 or membralin-1
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   highly
     spleen    
    Nervousbrainlimbic systemhippocampusdentate gyrus 
     plexus choroid    
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificgranular cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal and 5 C-terminal transmembrane domains
  • potential sites for N-myristoylation and for phosphorylation
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • critical role of membralin in motor neuron survival, suggesting a novel mechanism for early-onset motor neuron disease
  • is an ERAD component, whith a reduction of mRNA and protein levels in Alzheimerdisease (AD) brain, suggesting a critical role for ERAD in Alzheimer pathogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian serous carcinomas, in effusion carcinoma, higher than in solid tumor, as compared to ovarian surface epithelium
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS