basic FUNCTION
| putative modulator of exonuclease activity, required for cell cycle arrest at the G2 checkpoint in response to incompletly replicated or damaged DNA |
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plays roles in DNA repair (homologous recombination repair, and base-pair excision repair) and cell cycle checkpoint controls |
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may be regulating cellular processes as well by modulating transcription of multiple down-stream target genes |
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playing a role in telomere stability and homologous recombinational repair as a mechanism for promoting cell survival after ionizing radiation exposure |
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apoptosis cell cycle checkpoint control |
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cell cycle G2 checkpoint control gene |
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RAD9A, RAD9B plays a role in locating Claspin to sites of DNA damage, facilitating its role during the CHEK1-mediated checkpoint response |
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importance of RAD9A in preserving genomic integrity in the presence of catenated chromosomes and all types of DNA aberrations |
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can act as a sequence-specific transcription factor, modulating expression of a number of genes |
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contributes to prostate tumorigenesis by increasing not only tumor proliferation and survival but also tumor migration and invasion, anoikis resistance, and anchorage-independent growth |
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functions in repairing DNA double-strand breaks (DSBs) by homologous recombination and facilitates the process by cell cycle checkpoint control in response to DNA damage |
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RAD9A is essential for male fertility and for repair of DNA DSBs during meiotic prophase |
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RAD9A could affect both the ATRIP protein levels and DNA damage-induced ATRIP foci formation |