basic FUNCTION
| involved in transport from the endoplasmic reticulum to the golgi apparatus |
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regulates cell surface expression of CASR |
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SAR1A organization regulates membrane constriction |
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controls the assembly and fission of COPII vesicles |
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play critical roles in the assembly and budding of COPII-coated vesicles in the ER |
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SAR1A GTPase activity is critical for procollagen export |
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SAR1A and SAR1B proteins lower membrane rigidity at low concentrations, and at high concentrations, increase membrane rigidity |
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SAR1A, SAR1B GTPase coordinates the assembly of coat protein complex-II (COPII) at specific sites of the endoplasmic reticulum (ER) |
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SAR1A antagonizes the lipoprotein secretion-promoting activity of SAR1B, both isoforms modulate the expression of genes encoding cholesterol biosynthetic enzymes and the synthesis of cholesterol ( |
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SAR1A, SAR1B dimerization is responsible for the formation of constrictive membrane curvature |
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activated SAR1A introduces membrane curvature through its N-terminal amphiphatic helix at the ER-mitochondria interphase and thereby reducing contact size |
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regulates the size of ER-mitochondria contact sites through its effects on membrane curvature |
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GTPase cycle of SAR1A appears to be responsible for collagen VII exit from the ER |