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FLASH GENE
Symbol FRS2 contributors: mct/npt - updated : 02-10-2018
HGNC name fibroblast growth factor receptor substrate 2
HGNC id 16971
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 6883 - 508 - 2017 28077787
10 - 6876 - 508 - 2017 28077787
10 - 6911 - 508 - 2017 28077787
11 - 6997 - 508 - 2017 28077787
10 - 6929 - 508 - 2017 28077787
11 - 6940 - 508 - 2017 28077787
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinaryureter     Mus musculus
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier lininguroepithelium   Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal myristylation sites for localization to membranes, including the plasma membrane
  • a phosphotyrosine binding (PTB) domain for binding to RTKs, such as the fibroblast growth factor (FGF) receptor and neurotrophin receptor
  • four potential GRB2-binding sites
  • HOMOLOGY
    intraspecies homolog to FRS3
    Homologene
    FAMILY
    CATEGORY adaptor , signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • functioning as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation
  • playing a role in the induction of lens and retina through recruitment of FGF and PTPN11
  • plays a pivotal role in FGF-dependent activation of the Ras-MAP kinase, PI-3 kinase, and FRAP1 pathways in breast carcinoma cells
  • central mediator in FGF signaling (Minegishi 2009)
  • FGF/FRS2&
  • 945;-mediated signals prevent premature differentiation of heart progenitor cells through suppressing autophagy.
  • is an adaptor protein that plays a critical role in FGFR signaling
  • FRS2-PTPN11 complex is the key mediator of FGF signaling in lens development
  • is a previously unidentified component of VEGF receptors signaling
  • FRS2 signaling is critical for nephron progenitors
  • is an FGF receptor-associated protein required for activation of downstream signaling molecules that include those in the mitogen-activated protein and AKT1 kinase pathways
  • FRS2, FRS3 may act as an important node for FGF and neurotrophin signaling in postnatal hippocampal development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • FGFR/FRS2 signaling may play a functional role in the development of high-grade liposarcomas
  • central mediator for fibroblast growth factor signaling
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to GRB2 in response to FGF or nerve growth factor stimulation
  • bind to a tyrosine phosphatase, SHP2 (Minegishi 2009)
  • regulates ERK levels to control a self-renewal target HES1 and proliferation of FGF-responsive neural stem/progenitor cells
  • tyrosine phosphorylation of FRS2 mediates FGFR-dependent lens cell survival, providing a mechanistic basis for the unique fiber-differentiating capacity of FGFs on mammalian lens epithelial cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    consistently amplified in classic and dedifferentiated low-grade osteosarcoma (LGOS) but not in their histologic mimics
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • overexpressed FRS2 is a biomarker for Postate carcinoma diagnosis, prognosis and response to therapies
  • Therapy target
    ANIMAL & CELL MODELS