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FLASH GENE
Symbol PSMD14 contributors: mct - updated : 09-11-2016
HGNC name proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
HGNC id 16889
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 1734 - 310 - 2012 22909820
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Respiratoryalveolar macrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminus of PSMD14 mediates the binding to MITF and is sufficient to increase MITF transcriptional activity
  • JAB/MPN domain
  • a JAMM motif, essential for cell viability and mutations in the JAMM motif reduced MITF activation of promoters
  • HOMOLOGY
    interspecies homolog to yeast pad1
    Homologene
    FAMILY
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • responsible for substrate deubiquitination during proteasomal degradation
  • is responsible for substrate deubiquitination during proteasomal degradation
  • Ub protease PSMD14 resident in the 19S proteasome regulatory particle is required for processing poly-Ub formed in the DSB response
  • proteasomal PSMD14 is a key de-ubiquitinating enzyme that regulates ubiquitin conjugates generated in response to damage
  • represents a novel component regulating the switch from non-homologous end-joining to homologous recombination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc dependent protease
    protein
  • binding to TXNL1 (Andersen 2009)
  • PSMD14 and MITF interact in osteoclasts and this interaction is dependent on TNFSF11 signaling
  • acts independently of TP53BP1 in homologous recombination repair to promote RAD51 loading
  • deubiquitylase PSMD14 stabilizes E2F1 protein through binding to and deubiquitylating E2F1 and hyperactivated PSMD14-E2F1 regulation may contribute to the development of liver cancer 6)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in Alzheimer Disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS