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FLASH GENE

Symbol

SEC62

contributors: npt - updated : 24-04-2003

HGNC name	SEC62 homolog (S. cerevisiae)
HGNC id	11846

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	with two transcripts of 2.8 and 5.5 kb (Daimon)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed SEC62 8 - 6541 45 399 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       moderately Cardiovascular heart       highly Digestive liver       moderately Endocrine pancreas       moderately Nervous brain       moderately Reproductive male system prostate     moderately Respiratory lung       moderately Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid         Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to Drosophila Trp1
	homolog to yeast S.cerevisiae Sec62

Homologene

FAMILY

SEC62 family

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth

basic FUNCTION	performing post-translational protein translocation into the ER when involved in Sec61-Sec62-Sec63 complex
	performing the backward transport of ER proteins subject to the ubiquitin-proteasome-dependent degradation pathway when involved in Sec61-Sec62-Sec63 complex
	involved in protein transport

CELLULAR PROCESS

protein, post translation, targeting

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

forming a Sec61-Sec62-Sec63 complex

INTERACTION

DNA

RNA

small molecule

protein

binding to ribosome-free SEC61 complex and SEC63

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS