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FLASH GENE
Symbol FARP2 contributors: npt/mct - updated : 23-09-2009
HGNC name FERM, RhoGEF and pleckstrin domain protein 2
HGNC id 16460
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
27 - 3997 119.7 1054 - Miyamoto (2003)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately
Lymphoid/Immunespleen   moderately
Nervousbrain   highly
Urinarykidney   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two PH domains
  • HOMOLOGY
    interspecies homolog to Drosophila CG1283
    homolog to C.elegans frm-3
    Homologene
    FAMILY
    CATEGORY unknown/unspecified , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • plays an important role in the signaling pathway downstream of G protein-coupled receptors (Miyamoto 2003)
  • guanine-nucleotide exchange factors for CDC42 (Miyamoto 2003)
  • key molecule involved in the response of neuronal growth cones to class-3 semaphorins (Toyofuku 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in autism with deletion 2q37.3 (Feider 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS