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FLASH GENE
Symbol TLR10 contributors: mct/npt - updated : 17-02-2010
HGNC name toll-like receptor 10
HGNC id 15634
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 3088 - 811 - Chuang (2001)
4 - 3594 - 811 - Chuang (2001)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus    
Lymphoid/Immunelymph node    
Reproductivefemale systemoviduct   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Lymphoid/Immunelymphocyte
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • tandemly repeated extracellular leucine-rich motifs(LRR)
  • a cysteine-rich region
  • a transmembrane segment and a cytoplasmic domain
  • the toll homology domain common to the Toll and IL1 receptor genes (also called TIR domain), highly conserved signaling domain found in the intracellular regions, mediating receptor signal transduction through recruitment of adaptor proteins and playing critical roles in the innate immune response and inflammation (Nyman 2008)
  • HOMOLOGY
    interspecies homolog to Drosophila transmembrane receptor Toll
    intraspecies homolog to TOLL1,TOLL6
    Homologene
    FAMILY
  • toll-like receptor family
  • CATEGORY immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • transmembrane protein type I
  • TLR1, TLR2, TLR6, and TLR10 are displayed on the plasma membrane where they are best available to contact bacterial and fungal cell wall constituents
  • basic FUNCTION
  • pathogen component (pathogen recognition and activation of innate immunity), mediating the production of cytokines
  • play a major role in initiating innate immune responses against microbes (Barreiro 2009)
  • recognize specific pathogen-associated molecular patterns and to alarm immunocompetent cells to trigger an immune response (Muzio 2009)
  • playing a potential role in modulating Chronic Lymphocytic Leukaemia cell response in the context of specific antigen recognition (Muzio 2009)
  • TLR1, TLR2, TLR6, and TLR10, mediates immune responses to a variety of microbial cell wall components including lipoproteins and glycolipids
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS immunity/defense
    text immune response
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activating NF-kappaBs signaling pathway
  • cell & other
    REGULATION
    induced by in primary T regulatory (Treg) cells in a calcium-dependent fashion through TCR activation (Bell 2007)
    Other regulated by FOXP3 (regulates TLR10 expression in human T regulatory cells) (Bell 2007)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS