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FLASH GENE
Symbol IKZF5 contributors: mct - updated : 09-04-2020
HGNC name IKAROS family zinc finger 5 (Pegasus)
HGNC id 14283
RNA
TRANSCRIPTS type messenger
text three Pegasus transcripts in hemopoietic cell lines and in tissues (OMIM)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 4381 - 419 - 2000 10978333
5 - 4493 - 419 - 2000 10978333
5 - 4519 - 419 - 2000 10978333
5 - 4990 - 351 - 2000 10978333
5 - 4532 - 419 - 2000 10978333
5 - 4528 - 351 - 2000 10978333
5 - 4528
5 - 5003 - 351 - 2000 10978333
6 - 4640 - 419 - 2000 10978333
6 - 5111 - 351 - 2000 10978333
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
 vessel   highly
Digestiveesophagus   moderately
 liver    
Lymphoid/Immunelymph node   moderately
 spleen   moderately
 thymus   moderately
Nervousbrain    
 nerve   predominantly
Reproductivemale systemprostate   
Respiratoryrespiratory tracttrachea  moderately
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Lymphoid    
Muscularstriatumskeletal highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal clusters of zinc fingers domain important for DNA binding
  • a C-terminal clusters of zinc fingers domain that mediates homo- and heterotypic associations between family members
  • conjugated MetalloP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Zfpn1a5 (98.3 pc)
    homolog to murine Zfpn1a5 (96.6 pc)
    Homologene
    FAMILY Ikaros family of transcription factors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • implicated in the control of lymphoid development
  • is a novel transcriptional regulator of megakaryopoiesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • lymphoid development
  • transcriptional repressor
  • PATHWAY
    metabolism
    signaling
    a component
  • integral component of chromatin-remodeling complexes
  • homo or heterodimerizing with either other member of the family
  • INTERACTION
    DNA binding to GnnTGTnG
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) THC7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS