SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,chromatin/chromosome,heterochromosome
|
| intracellular,nucleus,chromatin/chromosome,centromere
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text
| associated with the centromere |
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pronucleus |
basic FUNCTION
| mediating gene silencing |
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contributing to the association of the heterochromatin with the inner nuclear membrane |
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is released from chromatin during the M phase of the cell cycle, upon H3 serine 10 phosphorylation |
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recognizing histone H3 tails methylated at 'Lys-9', leading to epigenetic repression |
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involved in transient repression of inducible promoters |
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present on the promoter together with the non-processive HNRNPA2B1 and functions as a negative regulator |
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novel role during the cellular response to oxidative stress |
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potentially acts as a rapid redox sensor, and it may connect the intracellular redox state with transcriptional regulation under various physiological conditions |
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WDR76 co-localizes to puncta with the heterochromatin proteins CBX1 and CBX5, which are also recruited to DNA damage but much less intensely than WDR76 |
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specific role for CBX1, CBX3, CBX5 in regulating SUV39H1 function under stress via a feedback mechanism that likely regulates heterochromatin formation |