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FLASH GENE

Symbol

ZFYVE1

contributors: mct - updated : 23-03-2016

HGNC name	zinc finger, FYVE domain containing 1
HGNC id	13180

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021260 12 - 4405 NP_067083 - 777 - 2001 11739631 NM_178441 9 - 2627 NP_848535 - 362 - 2001 11739631 NM_001281734 12 - 4463 NP_001268663 - 763 - 2001 11739631 NM_001281735 9 - 2641 NP_001268664 - 362 - 2001 11739631

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Lymphoid/Immune spleen         Nervous brain         Reproductive female system ovary         male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal C2H2 zinc finger motifs
	ER-targeting motif is necessary and sufficient for ER targeting but insufficient for omegasome targeting
	two C terminal zinc binding FYVVE domains

conjugated

MetalloP

HOMOLOGY

Homologene

FAMILY

zinc fingers family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic,vesicle
text	in nutrient-rich conditions, localizes to the ER membrane ubiquitously and to the Golgi apparatus, but autophagy is not induced
	GFP-ZFYVE1 has been shown to localize to the omegasome

basic FUNCTION	potentially involved in cellular trafficking
	is an indicator of the phagophore-associated PtdIns(3)P-enriched membrane formation from the endoplasmic reticulum

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	phosphatidyl inositol 3 phosphate binding protein
	TRIM13 interacts with p62/SQSTM1 and co-localizes with ZFYVE1
	actin filaments colocalized with ATG14, BECN1/Beclin1 and PtdIns3P-rich structures, and some of them have a typical omegasome shape stained with the double FYVE domain or ZFYVE1
	EMC6 interacted with both RAB5A and BECN1/Beclin 1 and colocalized with the omegasome marker ZFYVE1/DFCP1
	DACT1 increases autophagosome formation as indicated by elevated puncta formation of MAP1LC3A, ATG14 and ZFYVE1 (Double FYVE-containing protein 1)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS