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FLASH GENE
Symbol ST18 contributors: mct/npt - updated : 30/10/2008
HGNC name suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)
HGNC id 18695
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 - 6330 115 1047 - Jandrig (2004
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Lymphoid/Immunespleen    
Nervousbrain    
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
Text in the developing CNS
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six fingers of the C2HC type (configuration Cys-X5-Cys-X12-His-X4-Cys)
  • a SMC domain
  • HOMOLOGY
    interspecies ortholog to murine St18
    homolog to rattus St18
    Homologene
    FAMILY
  • myelin transcription factor 1 (Myt1) gene family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • suppressor of tumorogenicity (may be the same than TSG8E)
  • having the potential to act as transcriptional regulator
  • may have a regulatory function in a specific phase during neuronal differentiation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    breast carcinoma
    tumoral     --low  
    a 160 bp region within the promoter is hypermethylated in about 80p100 of the breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS