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FLASH GENE
Symbol ZDHHC6 contributors: mct - updated : 07-02-2024
HGNC name zinc finger, DHHC domain containing 6
HGNC id 19160
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2187 - 413 - 2017 28826475
12 - 3018 - 383 - 2017 28826475
10 - 2225 - 359 - 2017 28826475
11 - 2387 - 413 - 2017 28826475
11 - 2108 - 413 - 2017 28826475
11 - 2066 - 305 - 2017 28826475
11 - 2158 - 409 - 2017 28826475
11 - 2078 - 309 - 2017 28826475
11 - 2288 - 413 - 2017 28826475
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved Cys 4 zinc-finger like metal binding domain
  • a complex Cys-His region
  • DHHC/NEW1 domain, potentially involved in protein-protein or protein-DNA interaction
  • ER targeting signal in DHHC6 is conform to a KKXX motif, C-terminal pentapeptide sequences required for ER localization of DHHC4 and DHHC6
  • HOMOLOGY
    interspecies homolog to Drosophila DNZ1
    Homologene
    FAMILY
  • DHHC palmitoyltransferase family
  • DHHC/NEW1 subfamily
  • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • restricted localization of ZDHHC4 and ZDHHC6 to ER membranes
  • basic FUNCTION
  • putative transcription factor
  • association of ZDHHC6 and SELENOK is clearly important for immune cell functions and possibly other cell types
  • ZDHHC6 may be a broad specificity S-acyltransferase specialized for the modification of a diverse set of transmembrane proteins at the endoplasmic reticulum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • ZDHHC6, which modifies key proteins of the endoplasmic reticulum, is controlled by an upstream palmitoyltransferase, ZDHHC16, revealing the first palmitoylation cascade
  • SELENOK interacts with an enzyme in the ER membrane,ZDHHC6 and the SELENOK/ZDHHC6 complex catalyzes the transfer of acyl groups such as palmitate to cysteine residues in target proteins, i.e., palmitoylation
  • MTDH is palmitoylated at residue cysteine 75 (Cys75), by ZDHHC6 as a palmitoyltransferase and this palmitoylation regulates its biological activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    new therapeutic interventions that target SELENOK for treating cancers like melanoma
    immunologyinfectious 
    intracellular saturated fatty acid-dependent palmitoylation of MYD88 by ZDHHC6 is a therapeutic target of sepsis
    ANIMAL & CELL MODELS