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FLASH GENE
Symbol WDR18 contributors: mct - updated : 13-01-2014
HGNC name WD repeat domain 18
HGNC id 17956
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1551 - 432 - 2012 22190735
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   moderately
Endocrineneuroendocrinepituitary  moderately
Lymphoid/Immunetonsils   moderately
Nervousbrain    
Reproductivefemale systemuteruscervix predominantly
 female systemovary  highly
Respiratorylung   moderately
cell lineage
cell lines
fluid/secretion highly in blood, moderately in lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six WD repeats
  • HOMOLOGY
    interspecies homolog to dog WDR18 (89.8 pc)
    homolog to rattus Wdr18 (83.3 pc)
    homolog to murine Wdr18 (83.5 pc)
    Homologene
    FAMILY
  • WD repeat protein family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • may be mediating protein-protein interactions
  • is a bona fide checkpoint protein and WDR18 works together with TOPBP1 to promote DNA damage checkpoint signaling
  • CELLULAR PROCESS cell life
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LAS1L interacts with PELP1, and WDR18, the mammalian homologues of the budding yeast Rix1 complex, along with NOL9 and SENP3, to form a novel nucleolar complex that cofractionates with the 60S preribosomal subunit
  • associates with the C-terminus of TOPBP1
  • facilitates ATR-dependent CHEK1 phosphorylation via interacting with both C-terminus of TOPBP1 and CHEK1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS