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FLASH GENE
Symbol UBE2D3 contributors: mct/npt/pgu - updated : 01-02-2015
HGNC name ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
HGNC id 12476
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2383 - 147 - 2004 15280377
8 - 2591 - 147 - 2004 15280377
8 - 2359 - 147 - 2004 15280377
8 - 2240 - 147 - 2004 15280377
8 - 2233 - 147 - 2004 15280377
8 - 2187 - 147 - 2004 15280377
8 - 2151 - 147 - 2004 15280377
8 - 2623 - 148 - 2004 15280377
7 - 2006 - 149 - 2004 15280377
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • ubiquitin-conjugating enzyme family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • physiological ubiquitin-conjugating enzymes E2s for MDM2, which make a significant contribution to the maintenance of low levels of TP53 and MDM2 in unstressed cells
  • regulates DAPK3 accumulation in promyelocytic leukemia protein nuclear body (PML-NB) by interacting with DAPK3 and stimulating its ubiquitination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DAPK3-binding partner (induced ubiquitination of DAPK3)
  • interacts with RNF2, in a manner fairly typical of E2-E3 interactions
  • UBE2N, UBE2L3 and UBE2D2/3 synergistically contribute to PRKN-mediated mitophagy
  • cell & other
    REGULATION
    repressed by SNAI2 (directly represses the promoter of the UBE2D3 gene)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS