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FLASH GENE
Symbol TRIP13 contributors: mct/npt - updated : 01-06-2018
HGNC name thyroid hormone receptor interactor 13
HGNC id 12307
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2408 - 432 - 2017 28564602
9 - 1482 - 289 - 2017 28564602
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • AAA ATPase family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • endogenous TRIP13 localizes to kinetochores
  • basic FUNCTION
  • required for reciprocal distribution of HORMAD1 and HORMAD2 and the SYCP1/SC-component along chromosome axes (Wojtasz 2009)
  • required after strand invasion for completing a subset of recombination events, but possibly not those destined to be crossovers (Li 2007)
  • is a novel mitotic checkpoint-silencing protein
  • plays centrally important roles in the sequence of events leading to Mitotic Checkpoint Complex (MCC) disassembly and checkpoint inactivation
  • is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family
  • MAD2L1BP and TRIP13 are critical for inactivating MAD2L1
  • although MAD2L1BP enhanced TRIP13-mediated MAD2L1 conversion, it was not absolutely necessary for the process
  • paradigm of the roles of MAD2L1BP and TRIP13 in both checkpoint activation and inactivation
  • is critical for the inactivation of the spindle assembly checkpoint and is associated with the progression of certain cancers
  • unexpected dependency on TRIP13 in cells overexpressing MAD2L1
  • AAA+-ATPase that plays a key role in mitotic checkpoint complex inactivation and is associated with the progression of several cancers
  • is a key component of the spindle assembly checkpoint
  • TRIP13 might function through different pathways in mitosis and meiosis
  • TRIP13 might play a role during the first cleavage of the zygote
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRIP13, aided by the adapter protein MAD2L1BP, converts the HORMA-family spindle checkpoint protein MAD2L1 from a signaling-active 'closed' conformer to an inactive 'open' conformer
  • TRIP13, jointly with the MAD2L1BP, promotes the inactivation of the mitotic (spindle assembly) checkpoint by disassembling the mitotic checkpoint complex (MCC)
  • unexpected dependency on TRIP13 in cells overexpressing MAD2L1
  • TRIP13 regulates both MAD2L1 and meiotic HORMAD1, HORMAD2 by disassembling these HORMA domain-closure motif complexes
  • TRIP13-MAD2L1BP intercepts and disassembles free MCC not bound to anaphase-promoting complex/cyclosome (APC/C) through mediating the local unfolding of the MAD2L1 C-terminal region
  • is a negative regulator of the HORMA proteins, including HORMAD1 and HORMAD2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OOMD5 , MVA3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in early stages of non-small cell lung cancer (Kang 2008)
    tumoral     --over  
    promote lung adenocarcinoma tumor progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker potential biomarker for lung adenocarcinoma
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    therapeutic target for lung adenocarcinoma
    cancerdigestivecolon
    could be a potential target for CRC treatment
    ANIMAL & CELL MODELS
  • both male and female Trip13-knockout mice are infertile