basic FUNCTION
| required for reciprocal distribution of HORMAD1 and HORMAD2 and the SYCP1/SC-component along chromosome axes (Wojtasz 2009) |
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required after strand invasion for completing a subset of recombination events, but possibly not those destined to be crossovers (Li 2007) |
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is a novel mitotic checkpoint-silencing protein |
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plays centrally important roles in the sequence of events leading to Mitotic Checkpoint Complex (MCC) disassembly and checkpoint inactivation |
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is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family |
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MAD2L1BP and TRIP13 are critical for inactivating MAD2L1 |
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although MAD2L1BP enhanced TRIP13-mediated MAD2L1 conversion, it was not absolutely necessary for the process |
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paradigm of the roles of MAD2L1BP and TRIP13 in both checkpoint activation and inactivation |
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is critical for the inactivation of the spindle assembly checkpoint and is associated with the progression of certain cancers |
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unexpected dependency on TRIP13 in cells overexpressing MAD2L1 |
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AAA+-ATPase that plays a key role in mitotic checkpoint complex inactivation and is associated with the progression of several cancers |
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is a key component of the spindle assembly checkpoint |
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TRIP13 might function through different pathways in mitosis and meiosis |
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TRIP13 might play a role during the first cleavage of the zygote |