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FLASH GENE
Symbol STEAP2 contributors: mct - updated : 04-06-2014
HGNC name six transmembrane epithelial antigen of prostate 2
HGNC id 17885
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestivepancreas exocrine   lowly
Nervousbrain   lowly
Reproductivefemale systemovary  lowly
 male systemprostate  highly
Urinarykidney   lowly
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveepithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a long N-terminal tail predicted to have NADP+/NADPH oxidoreductase activity
  • six transmembrane domains
  • a NADP oxidoreductase coenzyme F420-dependent domain
  • HOMOLOGY
    interspecies homolog to rattus LOC312052
    ortholog to murine Steap2
    Homologene
    FAMILY STEAP family
    CATEGORY antigen , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text predominantly to the trans-Golgi network, and to the plasma membrane
    basic FUNCTION
  • may have an important role in the normal prostate cell as well as in prostate cancer progression
  • may be involved in the secretory/endocytic pathways
  • as a cell surface antigen, may be a potential diagnostic or therapeutic target in prostate cancer
  • STEAP1, STEAP2, STEAP3, STEAP4 share an innate activity as metalloreductases, indicating their importance in metal metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer
    tumoral     --over  
    in several types of human cancers, namely prostate, bladder, colon, pancreas, ovary, testis, breast, cervix, and Ewing sarcoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS