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FLASH GENE
Symbol SMARCE1 contributors: mct - updated : 10-05-2019
HGNC name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
HGNC id 11109
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2425 46.6 411 - 2010 20338169
- - - - - predominantly expressed in the nervous system 2009 19245665
  • truncated N-terminus
  • associate into protein complexes together with SMARCA4, SMARCA2, SMARCC1 and SMARCC2
  • contribute to functional SWI/SNF complexes regulating neurogenesis
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinelarge intestine   
     mouth   highly
     pharynx   highly
    Lymphoid/Immunespleen   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    Respiratoryalveolar macrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text
  • placenta
  • constitutively expressed during development
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative nuclear localization signal
  • one HMG domain
  • a coiled-coil domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text nuclear matrix
    basic FUNCTION
  • required for transcriptional activation of genes normally repressed by chromatin
  • required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases
  • accessory component of the remodeling complex, and a critical regulator of androgen receptor function
  • critical modulator of the androgen receptor (AR) that is capable of altering AR activity, coactivator function, and AR-dependent proliferation
  • important role as regulator of estrogen receptor functions in breast cancer cells
  • having a role within the SWI/SNF complex that is required for maintaining the proper subunit composition of the complex and cell cycle progression through the transcriptional regulation of a subset of cell cycle-related genes
  • involved in the repression of neuron specific genes
  • TSHZ3 and SMARCE1 cooperate to modulate MYOD activity on the MYOG promoter to regulate skeletal muscle differentiation
  • role for SMARCE1 as a metastasis factor, a prognosis marker and a therapeutic target
  • is a key driver of invasive progression in early-stage tumors
  • SMARCB1, SMARCD1 and SMARCE1 might act as novel pro-senescence factors in both normal and tumor human skin cells
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of five multiprotein chromatin remodelling complexes: Swi/Snf-A (BAF), Swi/Snf-B (PBAF), Brm, Brg1(I) and Brg1(II)
    INTERACTION
    DNA DNA binding
    RNA
    small molecule
    protein
  • binding to the SRC/p160 family of histone acetyltransferases (HATs) composed of NCOA1, NCOA2, and NCOA3
  • directly bind to the androgen receptor (AR) and is recruited to endogenous AR targets upon ligand activation
  • recruited to the AR DNA-binding domain/hinge region, which occurs concomitant with receptor activation
  • interacts with RCOR1, a protein that acts as a co-repressor of REST (RE1 silencing transcription factor), a transcription factor which represses neuronal genes in non-neuronal cells
  • interacted with SMARCA4 in oocytes and enhanced gene activation by thyroid hormone receptors cooperatively with SMARCA4
  • role of SMARCA4/SMARCE1-containing chromatin remodeling complexes in thyroid hormone receptors-regulated gene expression during postembryonic development
  • partner of TSHZ3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CSSSCE1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in AR-dependent prostatic adenocarcinoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • putative marker of metastatic potential that could be leveraged for therapeutic intervention
  • predictive marker of endometrial carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    may be a target for ovarian cancer therapy
    cancerreproductiveprostate
    blockade of AR-SMARCE1 interaction is a novel means to target agonist-induced AR function in prostate cancer, and provide the first evidence that abrogation of SWI/SNF function can be developed as a point of therapeutic intervention in prostate cancer
    cancerreproductivebreast
    targeting SMARCE1 could represent a new way to effectively inhibit the action of ESR1 in breast cancer
    ANIMAL & CELL MODELS
    Smarce1 is overexpressed in the hippocampus but not in the kidney of tau deficient mice