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FLASH GENE
Symbol SLC2A13 contributors: mct - updated : 18-03-2020
HGNC name solute carrier family 2 (facilitated glucose transporter), member 13
HGNC id 15956
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 7221 70.2 648 - 2015 26094765
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinnercochlea   Homo sapiens
Nervousbrainlimbic systemhippocampus predominantly Homo sapiens
 brainforebraincerebral cortex   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Hearing / Equilibriumcochlea cell Homo sapiens
Skin/Tegumentmelanocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text primitive neurectoderm,heart
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 12 predicted transmembrane domains
  • mono polymer heptamer
    HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • sugar transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • is expressed in marginal cells and basal cells of the stria vascularis,of the cochlea
  • basic FUNCTION
  • playing a key role in the control of myo-inositol brain metabolism (Uldry 2001)
  • is thus expressed in a vesicular compartment involved in activity-dependent regulation of myo-inositol uptake in neurons
  • can transport inositol triphosphate, indicating unanticipated intracellular functions for this transporter that may be relevant to mood control
  • represents a potential regulator of inositol signalling in neurons
  • can be a potential markers for Cancer Stem Cells (CSCs) in various tumors
  • novel GSAP (gamma-Secretase associated protein) that regulates A&
  • 946; production without affecting Notch cleavage
  • may play important roles in the homeostasis of cochlear fluids, for example by participating in pH regulation and osmoregulatio
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker SLC2A5 with SLC2A10, and SLC2A13, are potential prognostic biomarkers in acute myeloid leukemia
    Therapy target
    ANIMAL & CELL MODELS