basic FUNCTION
| histone-lysine N-methyltransferase activity |
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methylates histone H3 lysines 4 and 36, which are associated with open chromatin ) |
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its DNA cleavage activity, unlike those of other eukaryotic transposases, is not coupled to its sequence-specific DNA binding |
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SET and transposase domain protein that methylates histone H3 and promotes DNA double-strand break repair |
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enhances TOP2A decatenation, and this activity is repressed by automethylation |
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key factor that promotes restar t of stalled replication forks, implicated in the repair of collapsed forks |
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promotes cell proliferation, but it does not alter cell cycle distributions, or replication fork progression |
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fusion of a histone methylase and transposase protein that arose specifically in primates |
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having a potential function opposing transposases and may thus play a key role in suppressing translocations that underlie oncogenicity |
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DNA repair protein, localized to an induced double-strand break (DSB) and directly mediated the formation of H3K36me2 near the induced DSB |
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SET-transposase fusion protein that promotes nonhomologous end joining (NHEJ) repair |
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potential role for its endonuclease activity in promoting the joining of noncompatible ends |
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SET and transposase domain protein that promotes both DNA double-strand break (DSB) repair and restart of stalled replication forks |
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while both SETMAR and DCLRE1C are biochemically capable of resolving a variety of damaged DNA ends for the repair of complex double-strand breaks, DCLRE1C appears to act more efficiently in the context of other nonhomologous end joining proteins |
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chimeric SET-transposase protein that plays essential role(s) in non-homologous end joining (NHEJ) repair and replication fork restart |