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FLASH GENE
Symbol EXOC5 contributors: mct - updated : 19-06-2013
HGNC name exocyst complex component 5
HGNC id 10696
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 8522 - 708 - 1997 9119050
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,cytoplasm,cytoskeleton,microtubule
text
  • CDC42 colocalizes with EXOC5 at the primary cilium
  • basic FUNCTION
  • regulates primary ciliogenesis
  • required for the ciliary localization of polycystin-2, thus allowing for polycystin-2 function in cellular processes
  • CDC42 and EXOC5 function in the same pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDC42 biochemically interacts with EXOC5, a crucial component of the exocyst complex
  • interacts with PKD2 (the protein product of the polycystic kidney disease 2 gene), and, when disrupted, results in MAPK pathway activation
  • directly interacts with PARD6A, a member of the PAR complex that itself directly interacts with CDC42
  • CDC42 and EXOC5 cooperate in ciliogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS