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FLASH GENE

Symbol

RYBP

contributors: mct - updated : 14-01-2015

HGNC name	RING1 and YY1 binding protein
HGNC id	10480

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_012234 4 - 4678 NP_036366 24.69 228 - 2006 17070805

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Cardiovascular heart       highly Reproductive female system uterus         male system prostate     highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a zinc-finger domain

secondary structure

noncompact protein with little residual secondary structure, lacking a well-defined tertiary structure

HOMOLOGY

interspecies

ortholog to murine Rybp

Homologene

FAMILY

CATEGORY

transcription factor , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm

basic FUNCTION	involved in regulation of transcription
	induced apoptosis in various tumor cell lines, but not in primary fibroblasts or mesenchymal cells
	involved in the regulation of both cytoplasmic and nuclear events of apoptosis
	inducing cell-cycle arrest and is involved in the TP53 response to DNA damage, interacting with MDM2 and decreasing MDM2-mediated TP53 ubiquitination, leading to stabilization of TP53 and an increase in TP53 activity (Chen 2009)
	RYBP and IFT57 may functionally interact in the apoptotic processes that accompany normal murine neural development
	zinc finger protein with an essential role during embryonic development, which binds transcriptional factors, Polycomb products, and mediators of apoptosis

CELLULAR PROCESS	cell life, cell death/apoptosis
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

text	transcriptional repressor

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein	binding to the Polycomb transcriptional repressor complex and to the transcription factor YY1
	interacting specifically with the E2F2 and E2F3 family members (Schlisio 2002)
	interacting with apoptin (Danen-van Oorschot 2004)
	interacting with DED-containing proteins and encoding pro-apoptotic functions
	RYBP can synergize with IFT57 to enhance CASP8-mediated apoptosis and also appears to be essential for IFT57-mediated apoptosis
	interacting with MDM2 (Chen 2009)
	RYBP stimulates the activity of RNF2 toward H2AK119ub1, suggesting a central role in Polycomb repressive complex 1 function
	RYBP-Polycomb repressive complex 1 is recruited to target loci in embryonic stem cells and is also involved in XIST RNA-mediated silencing, the latter suggesting a wider role in Polycomb silencing
	CBX7 is necessary for recruitment of RNF2 to chromatin, whereas RYBP enhances the Polycomb repressive complex 1 enzymatic activity
	RYBP inhibits the polyubiquitination-mediated proteasomal degradation of RNF2 independently of its ubiquitin (Ub)-protein isopeptide ligase (E3) ligase activity
	RYBP modulates stability and function of RNF2 through targeting UBE3A

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS