basic FUNCTION
| only RhoBTB with a prenylation motif, associates with vesicles that are frequently found in the vicinity of microtubules, suggesting a participation in some aspects of vesicle trafficking (Berthold 2008) |
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tumor suppressors that might function as adaptors of CUL3-dependent ubiquitin ligase complexes (Berthold 2008) |
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play a part in the carcinogenic process through a mechanism that involves the decreased or abolished expression of the corresponding genes, or more rarely, mutations that result in impaired functioning of the protein, presumably leading to the accumulation of RhoBTB substrates and alterations of the cellular homeostasis (Berthold 2008) |
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RAB9A-regulated ATPase that may function in vesicle docking by uncoating transport vesicles at their target (Espinosa 2009) |
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regulates the S/G2 transition of the cell cycle by targeting CCNE for ubiquitylation |