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FLASH GENE
Symbol RHOBTB3 contributors: mct/npt - updated : 31-05-2014
HGNC name Rho-related BTB domain containing 3
HGNC id 18757
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 5566 - 611 - 2002 1242610
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveliver   moderately
Endocrinepancreas   moderately
Reproductivefemale systemovary  highly
 male systemtestis  moderately
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text fetal tissues, particularly brain, heart, and lung
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GTPase (guanosine triphosphatase) domain
  • a proline rich region
  • a tandem of two BTB (Broad-Complex, Tramtrack, and Bric a brac) domains
  • a prenylation motif
  • a C-terminal region of unknown function
  • HOMOLOGY
    Homologene
    FAMILY
  • Rho GTPase family
  • RHOBTB subfamily
  • CATEGORY enzyme , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    text
  • RAB9A Effector and Localized to the Golgi (Espinosa 2009)
  • co-localization between the HTR7 receptor and RHOBTB3 at the plasma membrane and in the endoplasmic reticulum
  • basic FUNCTION
  • only RhoBTB with a prenylation motif, associates with vesicles that are frequently found in the vicinity of microtubules, suggesting a participation in some aspects of vesicle trafficking (Berthold 2008)
  • tumor suppressors that might function as adaptors of CUL3-dependent ubiquitin ligase complexes (Berthold 2008)
  • play a part in the carcinogenic process through a mechanism that involves the decreased or abolished expression of the corresponding genes, or more rarely, mutations that result in impaired functioning of the protein, presumably leading to the accumulation of RhoBTB substrates and alterations of the cellular homeostasis (Berthold 2008)
  • RAB9A-regulated ATPase that may function in vesicle docking by uncoating transport vesicles at their target (Espinosa 2009)
  • regulates the S/G2 transition of the cell cycle by targeting CCNE for ubiquitylation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • RHOBTB2 and RHOBTB3 are capable of homo and heterodimerizing through the BTB domain region (Berthold 2008)
  • on the Golgi, RHOBTB3 bound CCNE as part of a Cullin3 (CUL3)-dependent RING-E3 ubiquitin ligase complex comprised of RHOBTB3, CUL3, and RBX1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with CUL3 (interaction requires the N-terminal region of CUL3 and the first BTB domain of RhoBTB) (Berthold 2008)
  • binds directly to RAB9A GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network (Espinosa 2009)
  • interacts with PLIN3 on membranes, we propose that it may function to release this cargo selection protein from vesicles to permit their efficient docking and fusion at the Golgi (Espinosa 2009)
  • RHOBTB3 is a new interaction partner of the HTR7 receptor, and strongly inhibits proteasomal degradation of HTR7 receptor
  • RHOBTB3, a Golgi-associated, Rho-related ATPase, regulates the S/G2 transition of the cell cycle by targeting CCNE for ubiquitylation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    arrested cells in S phase, triggered Golgi fragmentation, and elevated CCNE levels
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS