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FLASH GENE
Symbol IPO8 contributors: mct/npt - updated : 30-06-2021
HGNC name importin 8
HGNC id 9853
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
25 - 5208 120 1037 - 2016 27277970
21 - 4696 - 832 - 2016 27277970
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Reproductivemale systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RAN binding site
  • HOMOLOGY
    interspecies ortholog to murine Ipo8
    Homologene
    FAMILY
  • importin-beta protein family
  • karyopherin family of nuclear transport receptors
  • CATEGORY receptor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • nuclear import of ribosomal protein
  • nucleocytoplasmic transport
  • required for cytoplasmic miRNA-guided gene silencing and affects nuclear localization of AGO proteins (EIF2C) (Weinmann 2009)
  • having specificity factor in the miRNA pathway, which may fulfill additional functions in nuclear Argonaute import (Weinmann 2009)
  • can influence nuclear import of Ago proteins in cells (Weinmann 2009)
  • plays a major role in Ago-mediated gene silencing and in the cytoplasm, localizes together with Ago proteins to P bodies and is involved in efficient loading of Ago proteins onto a variety of different target mRNAs (Weinmann 2009)
  • contribute to the coordination of several critical steps of cerebral cortex development
  • plays a critical and non-redundant role in TGFB1 signaling during development
  • is a nuclear transport receptor
  • translocates cargo molecules such as proteins, RNAs, and ribonucleoprotein complexes into the nucleus in a RanGTP-dependent manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    component of miRNA-guided regulatory pathways (Weinmann 2009)
    a component
  • forming a trimeric complex with RANGAP1 and RANBP1
  • component of Ago (Argonaute) protein complexes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the nuclear pore complex (NPC)
  • binding RAN
  • interacts with Ago proteins and localizes to cytoplasmic processing bodies (P bodies), structures involved in RNA metabolism (Weinmann 2009)
  • KPNB1, XPO7 and IPO8 mediate the translocation of RELA into the nucleus
  • RUNX2 regulates IPO8 gene transcription, and may have a contributory role in osteoblast differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EOTAAFD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • IPO8 may be a marker reflecting human dental pulp inflammation
  • Therapy target
    ANIMAL & CELL MODELS