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FLASH GENE
Symbol RALY contributors: mct - updated : 16-09-2014
HGNC name RNA binding protein (autoantigenic, hnRNP-associated with lethal yellow)
HGNC id 15921
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 4790 - 305 - 2012 22994768
  • RALYL
  • expression of RALYL was significantly low in clear cell renal cell carcinoma and correlated with a poor prognosis in a large number of clinical samples
  • 9 - 4742 - 290 - 2012 22994768
    RALYS
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY heterogeneous nuclear ribonucleoproteins family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in many processes of mRNA metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RNA-dependent interactions of RALY with MATR3, PABPC1 and ELAVL1
  • protein-protein interaction of RALY with EIF4A3, FMRP, and HNRNPC
  • HNRNPH1, RALY, and TFG are proteins that specifically interact with the C-terminal domain of RBFOX1 and RBFOX2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to facial pigmented spots during aging
  • Variant & Polymorphism other
  • genetic variations in RALY/ASIP, contribute to the acquired amount of facial pigmented spots during aging, through pathways independent of the basal melanin production
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    may be a potential therapeutic target as well as a poor prognostic factor, in clear cell renal cell carcinoma
    ANIMAL & CELL MODELS