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FLASH GENE
Symbol PRPF18 contributors: mct - updated : 17-09-2019
HGNC name pre-mRNA processing factor 18
HGNC id 17351
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1670 - 342 - 2012 22213562
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
basic FUNCTION
  • PRPF18 facilitates the elongation reaction of viral polymerases by preventing the deleterious annealing of newly synthesized RNA to the template
  • may be required to maintain the structural integrity of viral ribonucleoprotein (vRNP) for processive template reading
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLU7 and PRPF18, which promote exon ligation, bind together to the PRPF8 RNase H-like domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS