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FLASH GENE

Symbol

PIGS

contributors: np/mct - updated : 25-10-2018

HGNC name	phosphatidylinositol glycan anchor biosynthesis, class S
HGNC id	14937

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_033198 12 - 2873 NP_149975 - 555 - 2001 11483512

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to S.cerevisiae gpi17p

Homologene

FAMILY

PIGS family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION

required for attachment of GPI anchor to proteins, transamidase activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	complexing with PIGK, PIGI, GAA1
	PIGS and PIGT are components of the GPI transamidase complex and are essential for the formation of the carbonyl intermediates necessary when the transamidase complex transfers the GPI group to the protein

INTERACTION

DNA

RNA

small molecule

protein

PIGT, PIGU, and GPAA1 may form a core complex associated by PIGS, and these four subunits may stabilize PIGK, triggering GPI anchoring reactions

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

GPIBD18

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS