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FLASH GENE
Symbol PGLYRP1 contributors: mct - updated : 09-01-2015
HGNC name peptidoglycan recognition protein 1
HGNC id 8904
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 972 - 196 - 2004 15572450
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  lowly
 liver   lowly
Lymphoid/Immunespleen   lowly
 thymus   lowly
Respiratorylung   lowly
Urinarykidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow    Mus musculus
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Respiratoryalveolar macrophage Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal signal peptide
  • extracellular PGRP domains III, II, and I
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • N-acetylmuramoyl-L-alanine amidase 2 family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text secreted protein
    basic FUNCTION
  • peptidoglycan receptor activity involved in innate immune response to Gram-positive bacteria
  • plays an important role both in antibacterial defenses and several inflammatory diseases
  • binding to and inhibiting the growth of S.aureus and E.coli
  • mediates antibacterial host defense
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text innate immune response
    PATHWAY
    metabolism
    signaling
    a component
  • PGLYRP1 forms with HSPA4 a stable complex with cytotoxic and antitumor activity
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • formation of PGLYRP1-S100A4 complex had virtually no effect on the role of S100A4 in the regulation of intracellular Ca2+ metabolism
  • HSPBP1 incapacitates the HSPA4-PGLYRP1 complex
  • cell & other
  • binding to gram-positive bacteria, B. subtilis and M. luteus, with high affinity
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • chimeric mice lacking Pglyrp1 on hematopoietic cells, not structural cells, showed a reduction in house dust mite (HDM)-induced eosinophilic and lymphocytic airway inflammation